the preventive effect of brassica napus l. oil on pathophysiological changes of respiratory system in experimental asthmatic rat
نویسندگان
چکیده
objective: asthma is an airway complex disease defined by reversible airway narrowing and obstruction, chronic airway inflammation, airway hyperresponsiveness, and tissue remodeling. the purpose of this study was to determine the effect of brassica napus l. (b. napus) on airway pathologic changes in a rat model of asthma. materials and methods: twenty-four rats were divided into 4 groups: control, asthmatic, asthmatic treated with 0.5 mg/kg b. napus oil, and asthmatic treated with 0.75 mg/kg b. napus oil. to induce the experimental asthma, rats in groups 2, 3, and 4 received an i.p. injection of ovalbumin and aerosolized ovalbumin. simultaneously, rats in groups 3 and 4 received b. napus oil daily by gavage. after 31 days, in all groups, thoracotomy was done and lung tissue samples were taken. for pathological evaluation, microscopic slides were prepared. the eosinophil numbers in the submucosal layer and thicknesses of smooth muscle layer of bronchioles were detected. results: eosinophil numbers in the submucosal layer, as well as smooth muscle layer thicknesses were significantly lower in the rat group treated with 0.75 mg/kg b. napus oil as compared with asthmatic group (p<0.01, p<0.05). conclusion: b. napus could be useful as adjuvant therapy in rat model of asthma. this effect was probably related to its antioxidants componentsthat reduce the levels of inflammatory mediators such as leukotrienes, il-4, il-5, and il-13.
منابع مشابه
The preventive effect of Brassica napus L. oil on pathophysiological changes of respiratory system in experimental asthmatic rat
Objective: Asthma is an airway complex disease defined by reversible airway narrowing and obstruction, chronic airway inflammation, airway hyperresponsiveness, and tissue remodeling. The purpose of this study was to determine the effect of Brassica napus L. (B. napus) on airway pathologic changes in a rat model of asthma. Materials and Methods: Twenty-four rats were divided into 4 groups: contr...
متن کاملThe preventive effect of Brassica napus L. oil on pathophysiological changes of respiratory system in experimental asthmatic rat
OBJECTIVE Asthma is an airway complex disease defined by reversible airway narrowing and obstruction, chronic airway inflammation, airway hyperresponsiveness, and tissue remodeling. The purpose of this study was to determine the effect of Brassica napus L. (B. napus) on airway pathologic changes in a rat model of asthma. MATERIALS AND METHODS Twenty-four rats were divided into 4 groups: contr...
متن کاملthe washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests
در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است
15 صفحه اولthe effect of taftan pozzolan on the compressive strength of concrete in the environmental conditions of oman sea (chabahar port)
cement is an essential ingredient in the concrete buildings. for production of cement considerable amount of fossil fuel and electrical energy is consumed. on the other hand for generating one tone of portland cement, nearly one ton of carbon dioxide is released. it shows that 7 percent of the total released carbon dioxide in the world relates to the cement industry. considering ecological issu...
the effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
the effect of learning strategies on the speaking ability of iranian students in the context of language institutes
the effect of learning strategies on the speaking ability of iranian students in the context of language institutes abstract language learning strategies are of the most important factors that help language learners to learn a foreign language and how they can deal with the four language skills specifically speaking skill effectively. acknowledging the great impact of learning strategies...
منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
avicenna journal of phytomedicineجلد ۳، شماره ۱، صفحات ۵۶-۶۳
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023